[Pharmacokinetics] Naatifen hydrochloride: External single dose of 1% naatifen hydrochloride cream for healthy people, about 6% of it is absorbed. Naatifen hydrochloride and its metabolites excreted through urine and feces, with a half-life of about 2 to 3 days. The concentration of naftiofen hydrochloride is sufficient to inhibit the growth of skin fungi after passing through the epidermis.
酮康唑：在Beagle 犬的正常皮肤和擦伤的皮肤上涂擦2%的酮康唑乳膏，剂量80mg/天，连用28 天，血中未检出药物（最低检出限度为2ng/ml）。健康志愿者单剂外用2%酮康唑乳膏于胸、背和手臂处，72 小时内血中未检出药物（最低检出限度为5ng/ml）。
Ketoconazole: Apply 2% ketoconazole cream on the normal skin and abrasioned skin of Beagle dogs at a dose of 80mg/day for 28 days consecutively, no detectable drug in the blood (limit of detection was 2ng/ml). A single dose of 2% ketoconazole cream was applied on the chest, back and arms of healthy volunteers, and no drug was detected in the blood within 72 hours (limit of detection was 5 ng/ml).