The patient, ***, female, 7 years old, was hospitalized with "oliguria, anuria for more than 20 days". The patient vomited frequently without inducement more than 20 days ago, more than 10 times per day, moderate volume, non-bile-like fluid, no brown substance, no abdominal pain or diarrhea, accompanied by urine volume reduce. The next day showed paroxysmal cough, not violently, with a small amount of sputum in the throat which was hard to cough out, had shortness of breath, no asthma, spasmodic cough, fever, orthopnea, cyanosis, or sweating, was treated with "amoxicillin, omeprazole, clarithromycin" orally twice in the local hospital, poor effect, the vomit, cough, shortness of breath had not been improved, was treated with "ECG, oxygen inhalation, saline volume expansion, furosemide IVP " once in the Affiliated Hospital of Jiangsu University, poor effect , blood pressure was relatively high , 140-150/105-112mmHg, so was transferred to our hospital on 26 February 2015. During the transit, heart rate reduced twice, SpO2 reduced significantly, was given anti-infection and symptomatic treatment in our ICU, but the condition got worse, appeared coma, multiple organ failure (heart, brain, lung, kidney, digestive system; coma, heart failure, respiratory failure, renal failure, liver failure, myocardial enzyme increase, gastrointestinal bleeding), treated with mechanical ventilation, ECG monitoring and cardiopulmonary resuscitation, CPR, 27 February critical value feedback TnI:4.485ng/ml , and sodium fructose diphosphate was given to protect myocardium. Repeated blood biochemical showed abnormal renal function.After the hospital consultant, the diagnose are"1. Viral encephalitis (brainstem) 2. Severe pneumonia 3.MOF.